I'd start from scratch
Turn off your computer & unplug the X45
boot up and uninstall all the saitek software then reboot
install the software again - then when prompted hook up the X45
when installing the software, just click next - be sure to install the advance option as that is the profile editor
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I just followed the saitek instructions and didn't have a problem.
If you use my profile, you need to reset the rocker in the throttle back to rudder axis as I have it set for aileron trim as I use the CH PRO Peds for rudder
gl