4x6... umm any plans for an amp, subs, full range, mids, and so on?
for a full range loudspeaker never skimp on price. the number of coils and material the cone is made of are #1. frequency response is #2. location in the car is #3.
if they are to be rear speakers make sure they have a sturdy cone for bass response. bass is omnidirectional so it doesnt matter where they are or where they point.
mid-bass and mid-range are semi-directional. you want the sound to reflect directly to you if possible. most cars have an angled rear window that does ok. thats why most power and sound comes from the rear speakers. (why ford put the large speakers in the front in the early 90's i'll NEVER figure out)
high range sound is extreemly directional. you want this pointed directly at you. if it isn't it just "dissapears" in the mix. and the misic sounds muddy. (you've prolly heard a crappy stereo play rock and you cant hear the cymbals, or classical and you cant hear the tin of the brass. {though most classical enthusiasts have nice systems})
one of the best self installed car systems i heard was of an installer's of custom systems (go figure lol). he said most just want lame bass that you can hear 3 blocks away. his was almost that loud but CRYSTAL clear.. FULL range. he had put a pair of 4" mids on the door panels low. thats 2 on each door but you couldnt even see them. you could "feel" them though. listening to jazz the snare hits would almost make you piss the "snap" was so strong. they were amped so much because of their placement.
remember i said mid sounds (like a snare drum) were semi-directional. well that
can be overcome with power. lots of power. like 400 watts per side. otherwise you need them higher on the door (or at least not obstructed by the seat).
back to your question...
you are asking about a 4x6 which is usually a front speaker (round 4" another common front speaker)
rears are usually 6" or 6x9 or larger.
for a 4x6 if it has "line of sight" of the person listening i would recommend a straight "cone" speaker without a "tweeter" assembly above it kinda like this:
rockford fosgate like the speaker in the middle.. just a plain cone. (i know its a 5.25" but thats the idea)
anyway enough dmn typing for now i hate typing. hope this helps