This is as good time to upgrade your PC as any other. There is ALWAYS something revolutionary around the corner, you can add 1 year to estimates of "new super techx", unless you are rich and stupid enough to go with the first wave.
Look for MB reviews, usually Asus comes on top. The thing to look in them is northbridge and southbridge chipsets, there are few different chipset manufacturers around. Differences (usually related to stability) can be drastical especially if you drive at the edge of their limitations. And like gixer mentioned, Epox is reliable brand too, but can be harder to obtain.