I dont know what the performance loss was with the MK108, I doubt it was much but just enough to be noticable. And intrestingly enough you can feel it in AH as well..

BTW Crummp which data sheet are yiu refering to for the performance loss figures with MK108?
If you are looking at the two G14 models and K4 sheet it doesnt show a loss. Look closely, the 560km/h SL figure is for the G14ASM high altitude optimized AS variant which is armed "wie G-6" prolly meaning standard MG151 armament only. The other G14 is the G14-U4 (DB605AM) with MW50 and armed "wie G-6/U4" meaning it has the performance degrading MK108 armament - this model makes the 568km/h at SL, but is slower at high alt.
Might be just a CG thing, but I'm kinda doubtful about the potential impact as the guns and ammo are allready mounted pretty close to CG anyway.
There wasnt any extra bigger hole for the gun tube in the spinner, it was pretty much the same size through the whole 109 G and K series..
The only external differences were IIRC a small gun gas vent on the lower right cowl, a new hatch for the gun's air supply filling connection, and possibly a spent case discharge port on the bottom. Though I'm aware of some debate whether the last item was actually fitted to the G models with MK108, but it certainly was to the K4.
So its a mystery exactly what the performance loss is or why, except that it prolly has to do with the MK108s extra weight more than other factors.