I shot a rabbit the other day at my moms house, I don't have a pellet gun. So, I went and got my dads .22LR and shot it. Standing right off the porch, shot it across the field, 3-4 acres. Died first shot. Least he was dead when I walked over to him.
-Edit- in the past, i've even killed a couple coyotes with the 22LR. But, i've killed more with the 22-250. -Edit-
ps. 22LR is good for killing prarie dogs at short-to medium distance. long range the 22.250 was best. 220 swift was even better.