I run all the spyware checks to make sure nothing else is connecting to the outside world, turned off auto-update completely and just right click the tray icon, select "Disable AntiVirus Auto-Protect," right click again, select "Disable Norten Internet Security." On both boxes select "Until System Restart." Wait for the "You are unprotected" thing to show up, click OK, and start the game.
When you're done, right click it and select the "Enable" versions of the above.