I'd put Pitt in as D'Aconia but put another huge actor in as Galt... Maybe even Tom Hanks. Someone who you know can be humble but strong enough to make the sacrifice.
Reardon... That needs to be someone very strong. Maybe Hanks as Reardon? Gotta be strong but with a beliveable weakness for Dagny. Her agents would never let her do it, but I'm imagining Nicole Kidman for Mrs. Reardon. Haughty and proud...
Liberals hate me for it, but I try to live that book. Damned looters, all of them. Ayn Rand was a radical, but like Orwell she had a no-kidding crystal ball she drew from when she wrote her books.