Next big game? My vote is for "Spore". You can google a demo video on it, and it's getting some good press at E3. You start as a single cell organism in a pac-man style game, and you begin evolving. The next phase of the game takes your evolved organism into a "first-person eater". Eventually it becomes a tribe (and RTS game). From there you continue to expand over the continent, then world, then solar system, then the entire galaxy in the sandbox mode from hell.
That, or World of Warcraft: Burning Crusade expansion. With 2.2 million subscribers, it's a garuanteed hit.
edit: I think some of y'alls interests are so far from mainstream, I wouldn't get your hopes up =P I think the coolest gaming physics I've seen so far were from Lucasart's booth. The Indiana Jones game due out in '07 has definately taken ragdoll phsyics up a notch. They've also got some other IP they're using with it in an upcoming Star Wars title that is supposed to have very accurate materials modelling. Glass breaks like glass, wood breaks like wood, metal bends & tears like it should. The guy they put in charge over there is very sharp.