Tried twice (suicide) when I was a teenager, was diagnosed with depression.(I've always said that those who were "serious" about suicide aren't here to tell about it)
I've lived with it, and overcome by bettering myself esteem, doesn't work for everyone, but it worked for me. Drugs just seem to gloss over self-realization, though my bouts of depression are mild compared to my sister, who must be on prozac or she racks up $100,000 credit card bills...