Another challenging question.
My first thought would be the U.S. Iron. Out of the dark, some P51, P47, P38 perhaps, and some F4U.
Of natural enemies, emmm, P38G and 109F, HurryI and A6M2, Spit I and 109E, SpitV and 109F, FM2 and Ki61, C202 and SpitV/P38G, and so on and on. Bugger you Hap, I'm going to be pondering on this all day and going to the TA

The reason I put my bucks on the KI before is BTW that the 250 miles speed isn't that high. Don't think a 190 would get away with the zoom, and after that it's turning and diving, etc.