Yeah, every little change in the airframe or loadout has an effect on the performance of the plane. Even whatg seems like t would be good can be bad, and vice versa. For example-
Recommended changes to the airframe of the XP-38 and it effect on airspeed:
Redesign Prestone Coolant Radiators..... +8 MPH
Improve blower installation..... +4 MPH
Non-Retracting Oil Cooler Inlet..... +3 MPH
Reduce size of exhaust cooling duct..... +2 MPH
reduce weight by 800-1,000 pounds..... +2 MPH
Increase H-stab area by 7sq.ft...... -1.2 MPH
Add armament..... -7.8 MPH
Net Gain..... +10 MPH
With provisions for external stores added (something the 38 wouldn't get for several years), the weight of 6MGs and ammo, full combat loadout of fuel, armor, radio equipment, not perfectly tuned experimental engine, I can see speed dropping by 30-40 MPH.