When I play this game, assuming that I have no applications (that I know about) running in the background, and that I've just had a fresh reboot, it only takes a few hours before the same thing happens every time.
After a few hours, I start to get massive hard-drive lag and choppiness. The choppiness goes hand-in-hand with constant repetitive accessing of the hard-drive. It makes gameplay impossible, the only way I've found to fix it is to reboot.
I have a Dell PentiumII 350, with 128mb ram, a 16mb TnT 3d card, a turtle beach sound card, and a 19 inch monitor. I don't have any significant problems with the computer other than when I play this game.
Sometimes I notice the problem when there are multiple cons in the area, other times noone is around as far as I can tell.
The only hardware issue I can think of is that I have played a lot of games over the past 3 years, installed and uninstalled over and over, and I've logged a LOT of hours on these games.
Any ideas?