If modelled correctly, it shouldn't stand a chance against a fighter. From what I know, it wasn't maneuverable... it'd be a good weapon platform against bombers and a good jabo.
I voted for Yak 3 this round, but I'm really indecisive between it and the Me 410. Yak 3 has a really low range, it should be around 15 minutes with 100%... on the other hand, the Hornisse won't be good for fighting, but it should be really fun for porking and attacking bombers... oh, well, neither of them will win, I know.
If I were to vote for a bomber, it would be the He111, it's a too big gap in the planeset... we have enough medium american bombers.