Well I can tell you just from a web design standpoint, that in the past it was considered pretty cool to have tables inside tables, invisible 1px gifs for alignment etc etc...now it is consider bad form although I haven't made the switch to CSS layouts yet myself.
I find myself struggling to get things to line up and look as intended in EVERY browser above the 5% margin AND for all the items to be as intended IE: images, text, etc
So in one browser, say Firefox 2.0 - I can have everything look great, but in another the heading bars are larger for two articles...why? Well, there are several reason and I have to configured arduously around those.
THEN you take two different computers, say my laptop with a glossy (lame) 15" widescreen, and a 19" desktop monitor (sony) - and you can see two different levels of hue/saturation/color on each monitor. On one screen, the website is 100% legible and perfect, on another...there are many issues like words blending too much into the background color and being hard to read, or the intended 'punch' items falling below the immediately viewable range with a widescreen versus a 'normal' screen.
There is a balance they must keep in mind, using just their test rigs will never suffice although I'm pretty sure they must have things like this in mind when they configure plane models. So it's always going to be difficult to please the masses, but you have to try - in the process...you please most of the people.
As long as I can read the thing and understand what it is meant to be, I'm happy..I just wish there was an easier way to look down toward my instruments...i'm probably going to map something on my joystick to do this as my hat options are all used.