Have you cleaned up the background proccesses? See the "Technical Support" forum. There is a sticky about Vista himts and tips. It is not complete, by any stretch of the imagination, and you are on you own if you decide to try and clean up the background processes.
If you do not try and clean up the background processes, your computer will need 2GB of RAM, at a minimum to run the game without swapping much. But the game will never play smoothly, even with that. There is nothing we can do to make it play smoothly on Vista if anyone insists on having it run all othe background processes it comes stock with.
Vista simply has too much overhead to run the flight simulation smoothly. I say there is nothing we can do. I guess we could dumb down the flight model and reduce the graphics level. Take a step backwards about 5 or 6 years years until hardware gets fast enough again to run Vista as fast as hardware can run XP today.