A few years ago I recall Gibson was putting together a Les Paul with a cat5 output...
Haven't heard about that idea in a few. But I have seen the flood of "reissues" out there. It's a funny culture. Most everything in high demand these days is a reproduction of "old school" technology. The most expensive guitars are antiques and bear the same technology as the higher priced equipment in the showrooms.
For guitarists, solid state is out, everyone's demanding tube signal paths (for the most part). And even the old stomp boxes are demanding big bucks over their modern counterparts.
For me, an auto-tuner would be cool but it better not affect the balance or looks of the instrument, and it better not cost a lot.
The other issue is programmability. It would need to allow for not only alternate tunings but also standard tunings alternately stepped to accommodate singers' pitch demands.
Sounds like a lot of buttons on my axe that I have long ago learned to live without.
Now if someone could effectively design a decent anti-suck processor.......
