Im a .45 caliber guy myself. .45 colt, .45 ACP, .454 Casull, .450 Marlin. It simplifies things and in all my years of shooting, carrying, and hunting, Ive become fond of bullets and calibers that make big entry/exit holes in critters.
Ive always been quite fond of the .44 mag too. Two of the most impressive put downs Ive seen involved the .44 mag "bar shoot" and the .357 mag 125 grn JHP, "OD shoot during robbery". We used to have a lot of guys who carried .44 mags.
While its true the most important thing is where you put the bullet, both self defense and hunting, and its true there are things outside your control. But its also true there is one thing "in" your control and thats the round and caliber you are using. Thing about .44s and .45s is that even chicken brained gangstas know exactly what they are when you pull them out. And well they should cause they will put the lights out in a BG real quick.
I like CCIs for my rifles and use a few different ones for handgun loads. I absolutely love the 300 grn Speer JSP for hunting loads in .44s,.45s, and .454s.