I fly with a microsoft sidewinder Prec 2 usb between my legs.
But I get by without a add on throttle or all those hats, buttons bells and whistles.
But then I tend to be kind of a minimalist where mapping stuff to stick is concerned.
Easier with joystick down there to actually use the keyboard.
For full hotas, I think your best bet would be to mount everything to a board. Either hinge/attach it to your desk or chair at a comfortable height. Ideally it would be setup so you could pivot it out of the way when not using it. But stable and solid when you are.
Think OUTSIDE the box