Max cruise settings in-game are a little dicey anyway, as they aren't really the maximum range settings. Since maximum range is affected by altitude, speed, and specific fuel consumption, those values on the E6B are more of a "sort-of". Every aircraft has a different "max cruise" at each altitude. For example, a fully loaded B-17 cannot even maintain altitude at 20,000 ft + using the max cruise setting on the E6B. So, obviously, its max cruise setting at that altitude is much higher.
For aircraft like the P-38 and P-47, your best range RPM are more like 1700-1800 RPM with MP settings in the upper 20's and lower 30's respectively.