I grew up with actual music, "yaknow the kind where people spend lifetimes learning an instrument", and Girl Talk just doesn't rate. Right now my 15yo is playing Mozart on the Baby Grand I bought him. He goes to a special music HS and has been playing since he was 5yo.
Thats music Dude. I'm sorry but Girl Talk just struck out with this middle aged cartoon pilot. In my day boys didn't call themselves "girls" no how. 
Music is music, who cares how long they have or haven't been playing whatever they play. 46 year olds like yourself obviously aren't open to anything new. As far as "Girl Talk" goes he is a former biomedical engineeriing student who decided he wanted to focus on music instead.
In my opinion his laptop is his instrument. He manipulates sounds and arranges them the way he feels. To take a sample of someone's music and transform it into a totally new sound is pretty unique. Laptop's are more used in today's music than ever before. Music must transform and this is where it's headed.
As much as I dont like rap I like it better then watching some whiteboy, whose mommie obviously had to much lead in her breast milk, prance around a stage acting like a rap artist with a Macbook.
Listen to the dude talk, he isn't an idiot. Seems like a guy who loves what he does and just wants everyone to have a good time. Do you have to like his music? I could care less. I just think people, like yourself, don't give artists like Girl Talk the respect they deserve.