I've got one, and use it always. The main issue is comfort and position of the unit. It's too tall by far to mount on a regular desk surface. For comfort's sake you must mount it LOWER than your joystick, so that when you rest your hand on the lever tops, it's a "usable" position, and not one that'll give you carpal tunnel.
I have a desk that has a sliding tray for the keyboard. I hate these. I move my keyboard around and depending on what games I'm playing or what I'm typing it'll be all over the place. So what I did was remount the sliding tray and mount the throttle quad onto THIS lower surface, which gave me an additional 5 inches or so to lower the height of my quad.
Without this I think I may have given up on it, or tried to mount it to the chair arm or something. The buttons are nice but unless you have the right wrist position/placement you won't be able to reach half of them with your thumb while your finger knuckles retain position on the lever-arm knobs.
I've got different modes mapped out in AH. 2-engine planes (most used) has from left to right, aileron trim, elev trim, RPM1, RPM2, THROT1, THROT2.
My alternate mode is elev trim, RPM1, THROT1 through THROT4 (for use with 4-engine bombers).
Since I use a hat view I have the most convenient button (right most) down-position mapped to "head up" that way I get 8-ways + up views on any of those 8 ways. Makes SA second nature after a little practice.
Definitely a quality piece of equipment, but the ergonomics need a little work.
One thing I hate about it is the physical detents on the rear most part of the axis motions. I wish I could open her up and remove those. It screws with fine-tuning trim and such.