Should I load the software, or are they plug and play?
CH representatives also recommend you install the control manager and use that to calibrate the CH devices, instead of the windows calibration.
I read one review and the person said it wouldn't work with other MFR's joysticks?
The CH pedals will work with other input devices, I'd like to read that review if you can find it again.
Any helpfull tips to getting them working quickly?
Many people, including CH representatives, recommend using all joysticks behind a powered hub. I never did until a few months ago and I find I have to calibrate less often now, but the joysticks and pedals did work just fine in Aces High when plugged into my motherboard.
It will take a little time getting used to the pedals, but you will be much happier with them than without them in a couple weeks. My other personal recommendation is to put anti-slip material under the pedals if you have a wood or tile floor. If you are putting the pedals on carpet, put the the 'coarse' side of adhesive velcro on the bottom side of the pedals so they don't move on you. They come with rubber feet but with a bit of time (and pet hair or dust) the pads can lose their effectiveness.