Wow,  how many F-15s have been lost in action since being active?
A dozen or so F-15s of various types "in action" or in combat support, if I recall correctly.  There are a half-dozen or so combat losses of F-15Es.  Another bunch of non-combat losses.  
If I recall correctly, this is the second GWOT F-15E aircraft and crew loss, neither from enemy fire.  F-15Es fly at night and in bad weather a lot, so that drives up the non-hostile-fire loss rate.  It's a hazardous environment, but that's where our mission is, doing stuff that the single-seat fighters and UAVs can't do.