One thing that I do notice is that the faster the bomber, the harder it is to be accurate. You have much less time to stabilize your speed and calibrate your sight after lining up on the target.
I did some very rough calcs at work today and a Bf109K-4 starting at sea level and climbing at 175mph to 28,500 feet would be about 35 miles behind by the time it reached 28,500ft if they started on exactly the same heading with the Mosquito XVI directly overhead and moving at 408mph. Even with unlimited fuel and WEP it would take over an hour for the Bf109K-4 to make up that ground.
Now, the Mossie XVI will likely have a MIL speed somewhat slower, so the Bf109K-4 with unlimited WEP and fuel would probably overtake it in only about half an hour instead.....
Basically, if you aren't in a jet or rocket, you will need to be lucky or to have planned your intercept.
