I find that when I stroke to a path it makes it look thick and blocky, as compared to a 1-pixel pen or brush.
I shift-click (which creates segments to your current point from the previous, in PS 5.1) and do a multi-faceted curve made out of straight segments. Often times you can do it so it looks passable.
I'll do the straight panels, lines, all on 1 layer, then on top of that will do the curves. If I totally screw up a curve I won't ruin the straights as I erase it. Then when satisfied, merge those layers into 1.