There is no way in any setup you should be running a Bf109E4 against those allied planes. The spit8 is arguably the most capable of the spitfires, as well. Doesn't roll as well as 16, but just as fast, climbs just as fast, and turns better. It's also faster than all of them up to about 20K, with the exception of being caught at sea level by a Fw190A8 (which... frankly... couldn't compete with a Spit8 even if it could catch it). Typhoon outruns all the axis planes up to 20k. Mossie matches or in some cases outruns them all up to 15k or so (with the exception of being run down at sea level by some).
It's very very very very lopsided and stacked against the axis.
EDIT: Main competition for mossies, tempests, spit8s would be 109G6 and maybe some G2s as well. Just for comparison.