As I've never had the CH throttle nor the X52, I can only comment based on second hand info and scouring info from the Internet about both. I was very interested in one or the other at one point. I thought (from an outsider's perspective, mind you) the x52 throttle looked like a better unit. It looked better with regards to button layout, ergonomics, and motion (it rotates, I think the CH slides?).
However, now that I use a 6-lever CH throttle quad that's a moot point. Perhaps not the most comfortable nor the best, but I find having those extra axes is a good tradeoff for me.
P.S. If you have never used a CH stick before, and find it uncomfortable to use the top hat, try mounting it lower. On a lower side table or possibly stick a platform on your chair's arm. You don't hug your palm to the entire stick, but you rest it on the buttons and you reach them all a lot better. That's not too far off from how the F-16 side stick is (and I think that was the real stick this CH stick is based on).