It's a wash in my car with the cost per mile being aroun the same. The car knows what you're feeding it and the extra 1.5-2mpg you gain offsets the cost of the fuel. I also pick up about 2 tenths and choose the better fuel for consistency. At least until the hottest day I've ever run happened. 
The fuel computer knows it too when I would fill up a second tank of 93 after 87 and back again. Very different mileage numbers and according to Vehicalc better results. YMMV, literally 
here's another question for ya............what brand gas do you use?
a friend of mine, and his wife have been experimenting. they've found that if they use sunoco cheap fuel, they gain about 3 to 5 miles per tankful. that's on her saturn vue with the honda v6, and his z4 with a 3.0 straight six. in his case, it could be partly due to driving, as he's been unemployed for a bit, and his foot is getting a bit lighter too. in her case, nothing's changed.
they're messing with shell right now, to see if the results are the same or not.