For Panzer's and M4's, come in high and from the rear and put the round just behind the turret. Can get them in 1-2 shots that way. Just be wary as the 25 doesn't like coming out of a dive all that well. Flaks are tricky for obvious reasons; 1) You are a BIG target, and 2) They can get you from any angle. The idea against flaks is to take long range shots at them from the sides. Will usually track them and/or turret them with a hit. After that, coming in from behind will be the finishing blow (though taking more flank shots will provide you with more of a target). First and foremost, try to turret them, then hope they don't have sups near by when you move in for the kill. The most common flak you'll encounter are Wirblewinds, so you'll be able to safely hit them from outside their range (just takes a little practice with aim). It's the Ostwinds you have to worry about. Their 37mm isn't that accurate, but you are a big enough target that it won't be too much of an issue (unless they are just out right horrid in aim). T-34's are a little tricky due to their sloped armor. I find it easier to track them first, then put a round into the spot just behind their turret. I haven't encountered any Panther's, Tiger's or King Tiger's while flying the 25, though the Panther will be the easiest of the 3.