I can relate to the Pancreatitus posters here, back when this game was first around I had a bad case of this, which happened to coincide with cancerous growths in my colon. My doctor initially told me that I had pancreatic cancer, and I fell into a really deep depression having lost a family member to this and knowing all about its survival rates etc. Well, it turned out God gave me a break that year, and while it turned out that my cancer was succesfully treated, and I suffered through the pancreatitus in the hospital for a far longer period of time compared to the gross time spent for treatments for cancer. Crazy.
I felt great from 2001 to 2009, and spent much of my time working in Afghanistan, Jordan, Africa, and the rest of the time in my native land of Alberta.
Then in 2009 I began to feel the sickest I've ever been, as the OP title asks, and the doctors couldn't figure out wtf was wrong with me. Five different doctors in two different countries, and none of the could figure out what was wrong with me and why I was in such agony. Multiple medical tests of every kind, and the only thing that really stood out was some returned colon polyps that had no cancer returns after being cut out. I was in constant pain, mainly my GI tract, but my joints and head as well. Of course not being able to work was really screwing with my life, and being in the middle of a divorce didn't help matters much either. I was on the verge of insanity, getting no answers and getting progressively worse. I decided to start researching things on my own, and after this strange rash showed up on my face a nurse I knew that was helping me out said I should get my anti nuclear antibody tested for Lupus and see a Rheumatlogist that specialized in Lupus as she suspected that's what was messing my system up so much.
Well it turns out that I was not just positive, but VERY positive for Lupus, and that I in fact had beaten the normal time it takes the Lupus patient to get a diagnosis, even though it was nearly a year and a half of hell prior to this. Unfortunately the treatment options for Lupus are very limited, and after a short time on Prednisone I developed a bad reaction to it, and it would send my blood sugar into the stratosphere and put me back into the hospital several times. This drug is the "heavy hitter" for treating Lupus, with anti-malarial drugs being the off-label 2nd tier treatment which doesn't help much being my only option until the first new drug for Lupus in 50 years is finally released (it's approved, just not available yet).
So to answer the question, right now is the sickest I've been, with a life-threatening illness with no cure in sight that affects 15 times more women than men...just my luck. It's considered by Hopkins to be one of the most difficult diseases to treat, with 19 different ways it affects the brain being identified alone, along with the system-wide issues it can cause by attacking any organ in the body at any time, without my rhyme or reason. Of course they prescribe very powerful painkillers if you want them, but all they do is cover the pains you get a little bit for a short while, and then you're back to square one.
