It wouldn't really be leathal as the NS-37. IIRC, it would be comperable to the 40mm Vickers S Gun on the hurricane IID.
Good aginst Panzer IV F's, and other light armored/soft targets, but a T-34 would probably be safe for the most part.
And the TseTse was being considered apparently, perhaps still is, yet the low production numbers of only 18 were built and 27 total aircraft built/converted didn't seem to disqualify it.
Also, I remember Pyro or one of the HTC crew saying that as long as individual weapons are correct for an aircraft variant, overall use of those weapons, and wether or not multiple weapons were used in combination is ignored.