Uptown, IMO, you're going to want to fly either the 109G-14 or the 109G-2 depending on the situation. If you need speed, but still want the flexibility of hitting ground targets, take the G15 with the 250kg bomb. If speed is less of a concern, up a G2 with the bomb.
With the G2, you trade a bit of speed and 13mm cowl guns in for vastly improved manuverability and a pair of 7.92mm's.
If however, you want a pure fighter, the 109K4 can't be beat. The engine is powerfull enough to get you out of most tight spots, and she is THE bench-mark for climbrate out of the Axis prop-fighters. Only the spitfire Mk 14 can outclimb it, and just barely at that.