I use Microsoft Security Essentials (free) for virus scanning, and Malware Bytes for errrm, well, malware. Also have spybot search and destroy on my machine, but only run that once a week or so.
So far not had any major problems, its picked up a couple of attempts to infect my machine and stopped it dead. Were I you Dago, I'd install everything that you want on your machine, get an imaging program, and take a disk image.
That way, if you do get infected, you can get back up and running somewhat faster than installing the OS, Drivers, Software, Updates etc.
Wurz