The Su-152 would be at a great disadvantage in AH. It's lack of turret and horrid reload rate (projectile and powder charge) would be the death of it.
The Su-100 would be a better fit for AH, imo. Fast reload rate and a superior AP capability would at least give it a chance.
I maintain the Su-100 or StuG III would be the best of the "turret-less" AFV's to be added to the game first. Both would be at a disadvantage from the get go because of the lack of a turret and the lack of 0° pivot capability (can't pivot in place).
Most claimed the M-18 was a great disadvantage in Aces High, as much as annoying a turret-less AFV would be in aces high, they served in combat in huge numbers and played a role.
I've been wanting the Jagdpanzer IV and L/70 models, one has a L/48 (same gun on a Panzer 4) other has a Panthers gun, turretless of course. However the extremely low silhouette would make it a very tough target to hit, with pretty good armor up front.
Tanking comes down to tactics, if used correctly tank hunters can do their job quite well as any other tank, just without a turret.