Have you ever timed it, Holmes?
no need to time it or guess, the downtime effect only happens once you get a strat under 50% ...
while it is true that 2 skilled B29 pilots can flatten the city, theres still no effect unless you also get a strat down under 50%. so figure 4 skilled pilots to have any meaningful effect on just one strat factory. darbar from 4 sets of buffs heading to HQ will almost certainly get a response from the rocketeers, which realistically means you need to double the buffs (for bomber losses and abandoned runs, those pesky 163s always seem to time their attacks for your drop

).
figure 6-8 formations to have a decent effect on 1 or 2 strats then, 8-12 if they cant all precision bomb from >20k.