Losing an engine on take off was often fatal for the Mossie. I am not sure about the Me410, but it seems likely it would not handle such an event well either.
I am not sure what to expect performancewise for the Me410. In many ways one might expect it to be similar to the Bf110, but the wing loading is so much higher on the Me410 it is hard to accept that they will be that similar.
I know the Me410 had changed wings to address the problem, but does anybody know what the Me210's handling problems were and if the Me410's changed wings completely fixed it?