Interesting, perhaps. Effective? Less so than you might think. You ever try flying the I-16 with 2x7mm and 1x12.7mm?
Think of it as maybe as strong as that. I've never gotten a kill with the I16 in that setup. I tried a few times but it never happened.
So yes, interesting in the same way the 109E-1 would be interesting (4x7mm). Might be fun to challenge one's self (like taking no cannons on a C205), but overall pretty weak weaponry.
EDIT: I think the 109F-2 is more interesting because I've learned a while back about the performance differences between the E-7, F-2, and the F-4. It wasn't quite as fast. Might make more interesting scenario match-ups as well.