Los Angeles, CA Population: 3,792,621 per 2010 Census
Lol you can't talk about major CA cities... the numbers are misleading because both the SF bay and LA are huge urban mish-mashes of 100s of cities and many counties all grown into each other without a discernible border (ie no gaps or free space, and all roads connect through).
for example..
17,877,006 Los Angeles CA, metro size (2010 census).
7,563,460 San Francisco/Oakland/San Jose Metro size (2010 census).
Edit:
302,157 Lincoln, Nebraska metro (2010 census).