Just as an FYI to the folks planning these, the CM tool only allows the disabling of certain weapons options. Just that entire option.
So, theoretically on a C205 you could disable the 20mm cannons and leave the 7mm wing guns, but you could NOT disable the 12.7mm cowl guns, because these are present on both (all) loadouts.
So you cannot disable a specific gun. You CAN disable a hangar loadout selection. If the gun you want to disable shows up in only one of those, yes you can disable it by not allowing those hangar choices, but if that gun is present in all selections you cannot remove all hangar options.