In my opinion, you need a different aircraft for intercept. The 410 takes about 11 minutes to reach 20k, which is enough time for a set of B-17s to drop and leave the sector, if you up when the base flashes. At that point, you're not intercepting, you're retaliating.
The 410, is a different verse of the 110's song. You can attack a strat raid, or similarly long flight, but you simply cannot function as a point defense interceptor.
Use a K4 if they're below 30k and time is short , and the Ta-152 for above that, regardless of time, escorts, or Satan giving you the evil eye.
The P-47 can also be effective at high altitude, but it suffers from poor climb, and armament that is (in my opinion) less well suited to the slashing passes you will want to use, and is worse against escorts, although it's more resistant to gunfire,accelerates better IIRC, and has more staying power as far as ammunition goes.