Especially the exhaust poppet valves are a problem. Actually poppet valves are pretty cack if you look at the gas flow, but you can see how much superficial development has been done if you look at the revs of a modern formula 1 car.
One of Harry Ricardo's motivations for working on the sleeve valve was the upper limit of output he foresaw with the poppet valve. The ports of the sleeve valves make for much easier aspiration. With modern materials you could make a really nice engine. But no one's going to bother now, the end of the piston engine is arguably in sight.

I've got a very rare book somewhere hereabouts entitled 'Some Unusual Engines'. Took me seven years to track a copy down and cost a lot of money. I can post some of the material if anyone's interested. Went out of print years ago.