Above 28,000ft it is not possible to run down the B-29 in the Bf110. With smart flying you may set yourself up for an intercept, but you need to make it count as the bombs will outrun you and you don't want to be parked on the six of a B-29 formation, though given your firepower you'd likely take one or more of them with you.
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I do it a few times every tour.
There are a few things you can do to ensure success.
1. Altitude...........Altitude will allow you to catch most any plane in the game with most any plane in the game if the advantage is enough.
2. Using the winds aloft directions to your advantage can put up to 60mph advantage in your favor if the buffs you are chasing are heading into a 30mph headwind while you have a 30mph tailwind.
3. Carrying enough fuel to cause the buffs to panic and descend or enough fuel to run them out of fuel.
3 B29s in 4 seconds over 28k chasing down with 60mph speed advantage mentioned above.
