I'm going to be doing it with my next build, with 4 SSDs and an Adaptec PCIe RAID card. I've had the hardware for a while, but haven't assembled the system.
My main concern was the lack of TRIM, and only relying on the SSDs' Garbage Colleciton. From what I've read, Windows can't use TRIM in RAID due to the way it sees the drives, as they're not presented as single AHCI drives.
I have two separate backup locations for my data, so the lack of redunancy isn't a big conern. I'm also banking on the SSD reliability.
Once I get the machine built, I'll do some benchmarks, both synthetic, and through applications, and compare them to my current rig. It won't be apples to apples, due to the CPU (i5-2500K OC'd vs i7-4970k OC'd), but I'm curious to see how it performs.