The new ransomware is a pain in the butt. It's coming out in variants so fast and so thick that most AV software is no longer able to keep up.
There is a new type of AV software hitting the market. Products like Cylance, Carbon Black, and I think Web Root has some goodness in it. These products have moved away from relying on signatures.
I get involved in a lot of security product testing (for work, alpha and beta code). In the last few months have been testing some new AV analysis stuff and boy what the desktop AV doesn't pick up scares the crap outta me. We have a pilot program at work to trial other software, and Cylance is one of them (unfortunately it's not available for consumers). It picked up stuff McAfee, Kaspersky, and Microsoft completely missed.
If anyone were to ask me for a home I would probably look at the Webroot products.