Arenas have no control over the keyboard mappings.
Are you running any anti-xxxx software on your computer?
If keys suddenly stop working, and you do not appear to be able to save settings, it usually means some anti-xxx software has decided Aces High is a virus. Not unusual for Norton, McAfee, AVG, Avast, or Kaspersky to do that. It seems it has gotten worse with Aces High III.