I like DDU - display driver uninstaller. Uninstall your current driver, then in safe mode run DDU, the reboot and install the new driver. I tried out nVidia Experience, giant POS IMO, doesn't really even do anything, just eats up processes and has extra background tasks running. Booo. Custom install = the driver, physx, and the sound drivers, no 3d or the other crap.
You can get away without doing it this way, but eventually parts of previous drivers may stick around and conflict with new ones - for the extra 3 minutes it's worth it to run DDU in safe mode IMO every time.