This one has been fairly long standing from what I've seen, as far as I know nobody has a consistent procedure for reproducing it.
When I changed to my new throttle, I had something similar happen. Just out of nowhere most/all of my mappings vanished a couple times during the course of setting it up. The weirdest one was I changed a button mapping while I was in flight, and everything on whichever control I did it on went blank. Axes and buttons.
Since then, my 2 rules for mappings are:
- After the session I make a change, take a backup of the Settings folder
- Never change mappings in flight, only in tower
Since I've been doing that, I haven't had a mishap with mappings since. I've had it happen as you describe as well, in between logins. Again, I've never seen someone show a procedure that can reproduce it, which really sucks.
The one thing with configuration on my setup that drives me nuts though is my microphone volume level gets reset at random in between logins. It's at the point I check my voice settings every time I log in. For my mic to work normally for people to hear me I need to set volume to full and boost to about 80%. If I log out and back in, it very often reverts to volume at about 70%, no boost. Sometimes, it doesn't. No idea why, but it seems to be something vaguely similar to the mapping issue.
Wiley.