No, it won't have an easy time surviving. That goes for both the Me410 and the Mosquito, and I want both.
The Mosquito FB.VI does about 345mph on the deck, where it did most of its operations, and peaks at 380mph at 13,000ft.
When you compare that to our 1943 German aircraft you can see that they could have trouble catching it. But in AH you will most likely run into Bf109G-10s and Fw190D-9s (if you run into its historical opposition), both of which were rare for the Mosquito to encounter in reality. The Bf109G-10 and Fw190D-9 will both easily run the Mosquito down and kill it, and that's saying nothing of the P-51, P-47, F4U, Yak-9U, La-5FN, La-7 and Typhoon that it never had to deal with.