Do you mean powerfule, as in hitting power, or powerful as in effectiveness?
Here is hitting power, weighted for effectiveness as a secondary attribute:
37mm Ns-37 - Yak-9T
40mm S-15 - Hurricane Mk IId
30mm Mk108 - Bf109G-6, Bf109G-10, Bf110G-2, Fw190A-8, Me262A-1, Ta152H-1
23mm VYa - Il-2
20mm Hispano Mk II / M2 20mm - F4U-1C, Hurricane Mk IIc, Mosquito Mk VI, P-38L, Seafire Mk IIc, Spitfire Mk Vb, Spitfire Mk IX, Spitfire Mk XIV, Typhoon Mk Ib
20mm Hispano Mk V - Tempest Mk V
20mm Ho-5 - Ki-61-I-KAIc, Ki-67
20mm Type 99 Model 2 - A6M5b, N1K2-J
20mm MG151/20 - Ar234B, Bf109F-4, Bf109G-2, Bf109G-6, Bf109G-10, Bf110G-2, C.205, Fw190A-5, Fw190A-8, Fw190F-8, Fw190D-9, Ta152H-1
20mm B-20 / ShVAK - La-5FN, La-7, Yak-9U
20mm MG/FF / Type 99 Model 1 - A6M2, Bf109E-4, Bf110C-4b, Fw190A-5
12.7mm Browning .50 Cal - A-20G, B-17G, B-26B, F4F-4, F4U-1, F4U-1D, F4U-4, F6F-5, FM2, Lancaster Mk III, P-38L, P-40B, P-40E, P-47D-11, P-47D-25, P-47D-30, P-51B, P-51D, SBD-5, Spitfire Mk IX, Spitfire Mk XIV,TBM-3
12.7mm Ho-103 - Ki-61-I-KAIc, Ki-67
12.7mm Breda SAFAT - C.202, C.205
12.7mm UBS - Yak-9T, Yak-9U
13mm MG131 - Bf109G-6, Bf109G-10, Fw190A-8, Fw190F-8, Fw190D-9
7.92mm MG17 - Bf109E-4, Bf109F-4, Bf109G-2, Bf110C-4b, Fw190F-5, Ju88A-4
7.7mm Browning .303 Cal - Boston Mk III, Hurricane Mk I, Hurricane Mk IId, Lancaster Mk III, Mosquito Mk VI, P-40B, Seafire Mk IIc, Spitfire Mk Ia, Spitfire Mk Vb, Spitfire Mk IX, Spitfire Mk XIV
7.7mm Type 97 - A6M2, A6M5b
7.7mm Brada SAFAT - C.202, C.205
7.6mm ShKAS - Il-2