They tryed the Hispano but The US felt it was generaly more bother than it was worh, It jamed a lot, so it was not untill late in the war when planes like the Helldiver(a serious pos) and the C hog came to be, but in the later case not to many were made.Even the 20MM's on the P 61 were often left off or prone to jaming.
They also were intrenched becuase of the Massproduction aspect of it all, they wored well and were available in large numbers, it was felt changing the horse in mid stream would slow up the works.
We wone the war by attration more than by having better weapons, look at the Sherman for example a seriously inferiour tank compare the the Panther, but they were reliable(mostly) and available in large quanties.